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    The selective modification of tissue proteins by acyl glucuronides and their potential drug-induced organ toxicity (especially liver) will also be discussed. 5.) Mechanistic Role of Acyl Glucuronides 183 Figure 1 Interrelationship between immune response and disposition of the drug (“hapten hypothesis”). Figure 1 Migration of the acyl group of the β-1-O-acyl glucuronide from C1 to C1, C6, and C7 of the glucuronic acid ring.

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