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    A careful examination of the GE region, including a retroflexed view from the stomach, is absolutely mandatory and biopsy samples should be taken of any suspicious area or lesion. Even so, the sensitivity of this method in excluding underlying cancer is reported to be around 80% or less, and as such, if high clinical suspicion remains, a second endoscopy with repeat biopsy samples may be necessary. Yes.

    However, these and other features, such as the age of the patient, are not highly specific and were shown in only one study to have a combined predictive value of 19%. Esophageal cancer may develop in the setting of achalasia, thought to result from longstanding stasis and secondary changes in the epithelium. 18. Is achalasia a premalignant condition?.

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