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    MPTP intoxication produces a parkinsonian syndrome in humans, provoked by specific damage to the nigrostriatal best buy generic viagra dopaminergic pathway. Although the battery used in this study was not extensive, the deficits observed in the patients resembled those of patients with idiopathic PD, characterized by memory deficits and frontal lobe-like symptoms, supporting the idea that the dopaminergic system mediates a specific set of cognitive functions. Effects of Levodopa on Cognition. The patients performed worse in some memory tasks, drawing, category naming, and the Stroop Word– Color Test.

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    (1999). J. European Journal of Neuroscience 15, 261–285. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. J., Polis, I., Koob, G.

    Khantzian, E. F., and Markou, A.

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    The enhanced propensity to self-administer drugs of abuse produced by stressors was linked to increased activation of the mesolimbic dopamine system mediated by glucocorticoid release (Piazza and best buy generic viagra Le Moal, 1994) (Fig. Rats receiving repeated injections of corticosterone acquired cocaine self-administration at a lower dose of cocaine than did rats that were administered vehicle (Mantsch et al., 1998). Administration of corticosterone caused rats that would not self-administer cocaine at low doses to self-administer cocaine. 5.11). Glucocorticoids have been shown to facilitate the locomotor activation associated with drugs of abuse (Marinelli et al., 1991, 1997b), and acute blockade of corticosterone secretion decreased the psychomotor response to cocaine (Marinelli et al., 1997a).