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Faster elimination in men was also observed for the clearance acquistare levitra online of digoxin (Yukawa et al. Because cytochrome-mediated metabolism is often the rate-limiting step, it may not be possible to detect any gender-related differences in conjugation reactions for these drugs. 1977. Frequently, conjugation acquistare levitra online reactions are the second metabolic step after the drug has been metabolized, involving relatively slower cytochromemediated hydroxylation. For example, the benzodiazepines temazepam and oxazepam, which are eliminated by conjugation, are cleared faster by men than by women (Divoll et al.
1980b). However, several drugs are metabolized solely by conjugation and appear to display gender-related differences in their elimination.
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